RESUMO
OBJECTIVES: Hiliar (pN1) and mediastinal lymph (pN2) nodal upstaging after surgery for early stage (Assuntos
Carcinoma Pulmonar de Células não Pequenas/diagnóstico
, Carcinoma Pulmonar de Células não Pequenas/cirurgia
, Neoplasias Pulmonares/diagnóstico
, Neoplasias Pulmonares/cirurgia
, Estadiamento de Neoplasias/métodos
, Cirurgia Torácica Vídeoassistida
, Toracotomia
, Idoso
, Algoritmos
, Carcinoma Pulmonar de Células não Pequenas/mortalidade
, Humanos
, Estimativa de Kaplan-Meier
, Neoplasias Pulmonares/mortalidade
, Metástase Linfática
, Pessoa de Meia-Idade
, Prognóstico
, Estudos Retrospectivos
, Fatores de Risco
, Cirurgia Torácica Vídeoassistida/métodos
, Toracotomia/métodos
, Resultado do Tratamento
, Carga Tumoral
RESUMO
OBJECTIVES: To investigate the capacity of a trained dog to identify LC in patients with malignant SPN. METHODS: We collected 90 exhaled gas samples from 30 patients with SPN (3 samples/patient). As controls we used 61 healthy volunteers and 18 COPD patients without SNP or LC, in each of whom we collected 5 exhaled gas samples (nâ¯=â¯395). The dog (Blat, a 4-year-old crossbreed between a Labrador Retriever and a Pitbull) and the methodology used were the same as previously reported by our group (see: https://drive.google.com/open?id=1R4mOtOtuZkTeb5iOEEv0K9r2kHKlPhWd). RESULTS: Of 30 patients with SPN, Blat recognized 27 of them as positive for LC and 3 as negative for LC. These results fully matched post-surgical pathological results. Sensibility was 0.97, Specificity 0.99, Positive Predictive value 0.97 and negative predictive value 0.99. The AUC of the ROC curve was 0.985. CONCLUSIONS: Trained dogs can identify accurately the malignant origin of SPN. It is now time to develop technology that can match canine olfaction and facilitate the implementation of this diagnostic approach in the clinic.